Revenue Cycle

What is modifier 25 used for?

Modifier 25 is an AMA CPT modifier appended to an E/M code to indicate the E/M service was significant and separately identifiable from a procedure performed on the same date.

Reviewed by Stanislav Sukhinin, CFALast reviewed April 9, 2026

Quick answer

Modifier 25 indicates that a significant, separately identifiable Evaluation and Management (E/M) service was performed by the same physician on the same day as a procedure, allowing both to be billed when properly documented.

The detail

Modifier 25 is among the most-used and most-audited modifiers in healthcare billing. The AMA CPT definition requires that the E/M service be 'significant and separately identifiable' from the procedure performed the same day. In practice, this means the E/M must address a problem distinct from the procedure, with documentation supporting the separate work. Common correct uses: a dermatology patient is seen for acne management (E/M with 99213-25) and during the same visit, a separate suspicious lesion is biopsied (11102). Common incorrect uses: routine pre-procedure exam for a planned procedure (the pre-procedure exam is bundled into the procedure RVU and cannot be billed separately). OIG has identified Modifier 25 misuse as a recurring audit target. Payer takebacks for incorrect modifier 25 use can extend back 5 to 7 years and reach hundreds of thousands of dollars for high-volume practices. Documentation must clearly show two distinct services with separate medical decision-making; without it, the modifier fails audit.

  • AMA CPT defines modifier 25 for significant, separately identifiable E/M services on the same day as a procedure.

    Source: AMA CPT

  • OIG and CMS have flagged modifier 25 as a recurring audit target due to high incidence of misuse.

    Source: OIG Compliance Resources

  • AAPC reports modifier 25 errors are among the top five causes of payer takebacks in dermatology, ENT, and urgent care.

    Source: AAPC

What this means for clinic owners

From Sorso

If you bill modifier 25 frequently, run a quarterly self-audit of charts. If your documentation does not show two clearly separate services with distinct decision-making, you have audit exposure. Fixing this proactively is one of the cheapest risk reductions available.

SS
Stanislav Sukhinin, CFA

Founder of Sorso. 19 years in corporate finance. Managed a $450M loan portfolio before building a fractional CFO firm exclusively for healthcare clinics.

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